Therapeutic responses to interferon-alpha in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP): Differing clinical responses to leukocyte-derived human interferon-alpha versus recombinant interferon-alpha
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چکیده
منابع مشابه
Biologic activity in a fragment of recombinant human interferon alpha.
To attempt to locate functionally important regions of the interferon (IFN) molecule, recombinant human IFN-alpha 2 was subjected to proteolytic digestion. The bacterial proteinase thermolysin produced two major complementary fragments, HuIFN-alpha 2-(1-110) and HuIFN-alpha 2-(111-153). After reduction with 2-mercaptoethanol and separation of the two major fragments on NaDodSO4/polyacrylamide g...
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OBJECTIVE Interferon is the first-choice therapy for HCV-positive mixed cryoglobulinemia, but only a small fraction of the patients show long-term recovery from the disease. In non-responders or relapsers, the second-line therapy (high dose interferon) generally is not effective. The aim of this study was to evaluate the effectiveness of leukocyte interferon as a second-line therapy in patients...
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Sir, (WellferonB , Glaxo-Wellcome), natural leukocyte (CilferonB , Janssen-Cilag) and raIFN (Intron-AB , Schering-Plough), 3 It is well known that prolonged administration of recombinant alpha interferon (raIFN) in several viral and malignant disMU intramuscularly, daily or on alternate days depending on the clinical outcome, evaluated as in our former paper (4). eases can be followed by loss o...
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Accepted 9 July 1997 Interferon-alpha (Hoffman-La Roche Ltd, Basel, Switzerland) is a highly purified, bacterially synthesized agent with antiviral, antiproliferative and immunomodulatory properties.' Interferon-alpha has been approved for the treatment of several types of cancer (eg, leukaemia, lymphoma, renal cell carcinoma and melanoma) and of chronic hepatitis.2'4 Usually causing flu-like s...
متن کاملHuman Interferon Alpha-2b: A Therapeutic Protein for Cancer Treatment
Human interferon alpha (hIFNα) is a wide biological activity cytokine that is used in hepatitis and cancer treatments. It regulates many genes that are involved in antiviral and antiproliferative activities. This mini review focuses on human interferon alpha-2b (hIFNα-2b) as therapeutic protein for cancer treatment. The review covers hIFNα-2b molecular characteristic and its molecular mechanism...
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ژورنال
عنوان ژورنال: International Journal of Case Reports and Images
سال: 2020
ISSN: 0976-3198
DOI: 10.5348/101118z01cz2020cs